By Phil Stewart and Steve Holland

WASHINGTON/PALM BEACH, Fla. (Reuters) – U.S President Donald Trump said on Thursday he ordered missile strikes against a Syrian airfield from which a deadly chemical weapons attack was launched, declaring he acted in America’s “national security interest” against Syrian President Bashar al-Assad.

U.S. officials said the military fired dozens of cruise missiles against the airbase controlled by Assad’s forces in response to the poison gas attack on Tuesday in a rebel-held area.

Facing his biggest foreign policy crisis since taking office in January, Trump took the toughest direct U.S. action yet in Syria’s six-year-old civil war, raising the risk of confrontation with Russia and Iran, Assad’s two main military backers.

“Years of previous attempts at changing Assad’s behavior have all failed and failed very dramatically,” Trump said from his resort in Mar-a-Lago where he was attending a summit with Chinese President Xi Jinping.

Some 50 Tomahawk missiles were launched from U.S. Navy warships, the USS Porter and USS Ross, in the eastern Mediterranean Sea, striking multiple targets – including the airstrip, aircraft and fuel stations – on the Shayrat Air Base, the officials said, speaking on condition of anonymity.

Damage estimates from the air strikes, which were conducted at 8:45 p.m. EDT, were not immediately known.

Syrian state TV said that “American aggression” had targeted a Syrian military base with “a number of missiles and cited a Syrian military source as saying the strike had “led to losses.”

Trump said: “Tonight I ordered a targeted military strike on the airfield in Syria from where the chemical attack was launched.

“It is in the vital national security interest of the United States to prevent and deter the spread and use of deadly chemical weapons,” Trump said.

“There can be no dispute that Syria used banned chemical weapons, violated its obligations under the chemical weapons convention and ignored the urging of the U.N. Security Council,” he added.

Trump ordered the air strikes just a day after he pointed the finger at Assad for this week’s chemical attack, which killed at least 70 people, many of them children, in the Syrian town of Khan Sheikhoun. The Syrian government has denied it was behind the attack.

Trump appeared to have opted for measured and targeted air strikes instead of a full-blown assault on Assad’s forces and installations.

The relatively quick response to the chemical attack came as Trump faced a growing list of global problems, from North Korea to China to Iran and Islamic State, and may have been intended to send a message to friends and foes alike of his resolve to use military force if deemed necessary.

Trump said earlier on Thursday that “something should happen” with Assad but did not specifically call for his ouster.

Officials from the Pentagon and State Department met all day to discuss plans for the missile strikes.

U.S. military action put the new president at odds with Russia, which has air and ground forces in Syria after intervening there on Assad’s side in 2015 and turning the tide against mostly Sunni Muslim rebel groups.

Trump has until now focused his Syria policy almost exclusively on defeating Islamic State militants in northern Syria, where U.S. special forces are supporting Arab and Kurdish armed groups.

The risks have grown worse since 2013, when Barack Obama, Trump’s predecessor, considered and then rejected ordering cruise missile air strikes in response to the use of chemical weapons by Assad’s loyalists.

Only last week, U.S. Ambassador to the United Nations Nikki Haley said the U.S. diplomatic policy on Syria for now was no longer focused on making Assad leave power, one of Obama’s aims.

But Trump said on Wednesday the gas attack in Idlib province, which sparked outrage around the world, had caused him to think again about Assad.

Speaking just before the airstrikes were announced, Russia’s deputy U.N. envoy, Vladimir Safronkov, warned of “negative consequences” if the United States went ahead with military action, saying the blame would be “on shoulders of those who initiated such doubtful and tragic enterprise.”

The deployment of military force against Assad marked a major reversal for Trump.

Obama’s set a “red line” in 2012 against Assad’s use of chemical weapons. When Obama then threatened military action after a 2013 chemical attack, Trump issued a series of tweets opposing the idea, including “Do NOT attack Syria, fix U.S.A.”

Obama backtracked on the air strikes, and after the latest attack, Trump was quick to blame his Democratic predecessor for “weakness and irresolution” that emboldened Assad.

(Additional reporting by Phil Stewart, Yara Bayoumy, Jonathan Landay, John Walcott, Idrees Ali, David Brunstromm and Matt Spetalnick in Washington; Writing by Matt Spetalnick and Jeff Mason; Editing by Yara Bayoumy and Peter Cooney)

IMAGE: FILE PHOTO: U.S. Navy guided-missile destroyer USS Ross is seen in the Bosphorus strait, returning from the Black Sea following a mission, in Istanbul, Turkey on June 3, 2015.   REUTERS/Murad Sezer/File Photo